Efficacy of Nanofat in Wound Healing: A Double-Blinded Randomized Controlled Trial

Nanofat has been shown to contain a variety of growth factors, antiinflammatory mediators, and adipose-derived stem cells, all of which may significantly contribute to the wound healing process. However, there is limited comparative clinical evidence supporting its use. This study aims to evaluate the effects of nanofat on wound healing in abdominoplasty by comparing outcomes between nanofat-treated and -nontreated wounds.

A double-blinded randomized controlled trial was conducted using a split-wound model. Each wound was divided and randomized into a nanofat-treated side and a nonnanofat-treated control side. Nanofat was prepared and injected along the wound margins using a standardized dose. Both patients and the surgeons evaluating the wounds were blinded to the treatment allocation. Wound outcomes were assessed 6 months postoperatively using the Observer Scale of the Patient and Observer Scar Assessment Scale.

Fifty lipoabdominoplasty patients were included in the study. Wound outcomes were significantly better in the nanofat group compared with the nonnanofat group across all assessed parameters, including vascularity, pigmentation, thickness, relief, pliability, surface area, and overall opinion ( P < 0.001). No oil cysts or fat necrosis were observed in the nanofat group.

Nanofat significantly improved wound outcomes in abdominoplasty patients without associated complications such as oil cysts or fat necrosis.