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Published on: August 13, 2019
Polycaprolactone Impregnated 3D Printed Nanohydroxyapatite for Sinus Augmentation: A Randomized Controlled Trial.
Poommarin Thammanoonkul1, Suwit Limpattamapanee2, Faungchat Thammarakcharoen3
1Center for Implant Dentistry and Periodontics, Faculty of Dentistry and Research Unit in Innovations in Periodontics, Oral Surgery and Advanced Technology in Implant Dentistry, Thammasat University, Bangkok, Thailand.
Polycaprolactone-impregnated 3D printed nano-hydroxyapatite (3DPHA-PCL) showed comparable dimensional stability but less new bone formation and lower implant survival than bovine bone (BB) in maxillary sinus floor elevation. Further research is needed for 3DPHA-PCL.
Area of Science:
- Oral and Maxillofacial Surgery
- Biomaterials Science
- Regenerative Dentistry
Background:
- Maxillary sinus floor elevation (MSFE) is a surgical procedure to increase bone height in the posterior maxilla.
- Bone substitute materials are crucial for successful augmentation in lateral MSFE.
- 3D printed nano-hydroxyapatite with polycaprolactone (3DPHA-PCL) is a novel biomaterial for bone regeneration.
Purpose of the Study:
- To compare the efficacy of 3DPHA-PCL versus bovine bone (BB) as bone substitutes in lateral maxillary sinus floor elevation (MSFE).
- To evaluate dimensional stability, new bone formation, and implant survival rates between the two materials.
Main Methods:
- A randomized controlled trial involving 22 sinuses (11 per group: BB and 3DPHA-PCL) across two centers.
- Lateral MSFE was performed, followed by serial cone-beam computed tomography (CBCT) scans at baseline, immediately post-op, 6 months, and 1 year.
- Bone core biopsies at implant placement underwent micro-CT and histomorphometric analyses.
Main Results:
- Augmented bone height and volume showed comparable, non-significant decreases in both groups post-MSFE.
- 3DPHA-PCL group exhibited significantly lower new bone formation (15.7-16.7%) compared to the BB group (25.6-26.3%).
- Two implant failures occurred in the 3DPHA-PCL group, whereas no failures were observed in the BB group.
Conclusions:
- While 3DPHA-PCL offers comparable dimensional stability to BB in lateral MSFE, it results in inferior new bone formation.
- The 3DPHA-PCL group showed reduced implant survival rates compared to the BB group.
- Long-term monitoring of 3DPHA-PCL is recommended to fully assess its clinical behavior and potential.
