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Updated: Feb 12, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 7, 2013
Early healing outcomes of re-entry sinus floor elevation after prior complete sinus membrane perforation: a pilot
Hyun-Chang Lim1, Seungil Shin2, Jong-Hyuk Chung2
1Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal-Implant Clinical Research Institute, Kyung Hee University Medical Center, Seoul, Korea. periodent81@gmail.com.
Purpose:
To determine the early healing outcomes of re-entry sinus floor elevation (SFE) after previous complete sinus membrane perforation.
Methods:
In six rabbits, the sinus membrane of one maxillary sinus was intentionally perforated (≥10 mm), and a collagen matrix was applied. SFE was performed on both sinuses after 8 weeks, establishing 2 groups: SFE after previous complete sinus membrane perforation (group SFE_ComPerf) and SFE with an intact sinus membrane (group SFE). The animals were euthanized 4 weeks after SFE. Micro-computed tomographic (micro-CT), histological, and histomorphometric analyses were performed.
Results:
On micro-CT, no statistically significant differences were observed in total augmented volume or mineralized tissue volume. Histologically, impaired new bone formation was observed near the sinus membrane in the SFE_ComPerf group. Histomorphometric analysis revealed that the area of newly formed bone was significantly smaller in group SFE_ComPerf than in group SFE (5.8±2.7 mm² vs. 10.5±1.9 mm², P<0.05). Such reduced bone formation in the SFE_ComPerf group was also evident in one region of interest (P<0.05).
Conclusions:
Complete sinus membrane perforation (>10 mm) may compromise new bone formation in re-entry SFE.
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