The lung pre-metastatic niche in osteosarcoma: Mechanism and therapeutic intervention
Daqing Wang1, Tianzhu Liu1, Baosheng Yin1
1Department of Joint Surgery and Sports Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Abstract:
Osteosarcoma (OS), the most common primary malignant bone tumor in children and adolescents, is characterized by its aggressive nature, high metastatic potential, and poor prognosis. The pre-metastatic niche (PMN) plays a crucial role in driving OS metastasis. This review provides an overview of the current understanding of lung PMN formation in OS and its contribution to metastatic progression. By highlighting the underlying mechanisms, this review offers new insights into potential therapeutic targets that could improve clinical outcomes for OS patients.
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