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Do we Have the Gut to Beat Thrombosis?
Konstantina Tsante1, Eleni Petrou1, Stavros Tsalas1
1Laboratory of Haematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Seminars in Thrombosis and Hemostasis
|October 7, 2025
Summary
The gut microbiome and its metabolites are emerging as key factors in blood clot formation (thromboembolism). Understanding these gut microbiome alterations offers new avenues for diagnosing and treating thrombotic diseases.
Area of Science:
- Cardiovascular Medicine
- Microbiome Research
- Thrombosis Pathophysiology
Background:
- Arterial and venous thromboembolism are leading causes of death globally.
- Conventional risk factors do not fully explain all thrombotic events.
- The gut microbiome is increasingly recognized for its role in cardiovascular health and thrombosis.
Purpose of the Study:
- To explore the gut microbiome's role in thromboembolic disease.
- To investigate microbiome-derived metabolites as potential biomarkers and therapeutic targets.
- To highlight the gut microbiome as a modifiable risk factor in thrombosis.
Main Methods:
- Review of recent evidence on gut microbiome and thrombosis.
- Analysis of the role of microbiome-derived metabolites in thrombotic pathophysiology.
- Exploration of the diagnostic and prognostic potential of these metabolites.
Main Results:
- Alterations in the gut microbiome significantly impact thrombotic risk.
- Microbiome-derived metabolites are implicated in the initiation and progression of thrombosis.
- These metabolites show potential as novel biomarkers and therapeutic targets.
Conclusions:
- The gut microbiome is a significant environmental factor in thromboembolic disease.
- Microbiome-derived metabolites offer dual utility as biomarkers and therapeutic targets.
- Further research into the gut microbiome's role in thrombosis is warranted.
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