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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Applications of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in heterocyclic ring formations
Ravi Varala1,2, Murali Mohan Achari Kamsali3, Mohamed Hussein4
1Scrips Pharma, Mallapur, Hyderabad 500076, Telangana, India. ravivarala@gmail.com.
Abstract:
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), a commercially readily available and easily handled bicyclic amidine base, is a renowned organic strong base and deprotonating agent with nucleophilic characteristics that has gained considerable significance in organic synthesis in recent years due its selectivity (chemo-, regio-, and stereo-); hence, this review article provides a concise update on several types of heterocyclic rings (spiro, fused/bridged, simple) synthesized using important techniques with DBU as a catalyst, solvent, base, or reactant, from June 2022 until the present.
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