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Dynamic Hydrogel-Based Cytomimetic Models for Chemical Information Conduction.

Tian Liu^1,2, Fen Li¹, Junlong Song²

¹Sustainable Materials and Chemistry Department of Wood Technology and Wood-based Composites University of Göttingen D-37077 Göttingen Germany.

|October 8, 2025

Summary

This summary is machine-generated.

Large cytomimetic models using hydrogels show proximity effects impacting enzyme cascade efficiency. This research explores their use in closed systems for chemical communication and oxygen stabilization.

Keywords:

cascade reactions cavitary hydrogel chemical information communication cytomimetic models

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Area of Science:

Biomimetic chemistry
Materials science
Chemical engineering

Background:

Micro- and nanoscale cytomimetic models are crucial for studying proximity effects in various applications.
Limited research exists on proximity effects in large-sized cytomimetic models for chemical communication over extended distances.

Purpose of the Study:

To investigate the proximity effect on chemical information communication in millimeter-sized cytomimetic models.
To evaluate the biocatalytic efficiency of enzyme cascade reactions within and between cytomimetic models.
To assess the performance of cytomimetic models in closed systems for oxygen stabilization.

Main Methods:

Fabrication of millimeter-sized spherical cavity hydrogels encapsulating enzymes: glucose oxidase (Gox), catalase (Cat), and horseradish peroxidase (HRP) using a one-step method.
Comparative analysis of biocatalytic efficiency for cascade reactions within a single model versus between two separated models.
Assessment of dissolved oxygen stabilization in closed systems utilizing different enzyme combinations (Gox/Cat and Gox/HRP).

Main Results:

Biocatalytic efficiency of cascade reactions between two separated cytomimetic models was 30.6% lower than within a single model due to proximity effects.
Closed System I (Gox/Cat) stabilized 66.7% of dissolved oxygen within 160 minutes.
Closed System II (Gox/HRP) showed lower dissolved oxygen stabilization (14.5% less) within 150 minutes, attributed to reduced oxygen circulation.

Conclusions:

Millimeter-sized hydrogel-based cytomimetic models demonstrate significant proximity effects influencing cascade reaction efficiency.
These models offer a promising platform for designing dynamic systems for applications like biosensing and controlled delivery.
The study provides insights into optimizing chemical communication and oxygen management in biomimetic systems.