Related Experiment Video
Updated: Jan 15, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Patterns of Glomerular Injury: Histopathological Classification and Clinical Correlation
Hussein Qasim1, Mohammad Abu Shugaer1, Shaima' Dibian1
1Department of Pathology and Laboratory Medicine, Jordan University of Science and Technology, Irbid, JOR.
None:
Glomerular diseases represent a diverse group of conditions that significantly contribute to chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. Understanding the histopathological patterns of glomerular injury is essential for accurate diagnosis, prognosis, and targeted therapy. This comprehensive review explores the morphologic, immunopathologic, and clinical characteristics of major glomerular disorders, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, immunoglobulin A nephropathy, lupus nephritis, and others. Histological classification is integrated with clinical syndromes, such as nephrotic and nephritic presentations, emphasizing the role of light microscopy, immunofluorescence, and electron microscopy in renal biopsy interpretation. Recent advances in molecular diagnostics, digital pathology, and artificial intelligence are also discussed, highlighting their transformative impact on precision nephrology. Through a multidisciplinary lens, this review underscores the prognostic and therapeutic implications of distinct histologic patterns and advocates for the continued evolution of clinicopathologic correlation in glomerular disease management.
Related Concept Videos
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Acute Kidney Injury II: Pathophysiology
Nephrotic Syndrome I : Introduction
Acute Kidney Injury III: Clinical Manifestations
Nephrons
Acute Kidney Injury I: Introduction

