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Updated: May 16, 2026
Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Effects of a 24-week multicomponent training program on functional capacity, persistent symptoms, body composition,
Angelica Danielevicz1, Mabel Diesel1, Carla Elane Silva Dos Santos1
1Sports Center, Federal University of Santa Catarina, University Campus, Florianópolis, Santa Catarina, Brazil.
Background:
COVID-19 can lead to reduced functional capacity, loss of muscle mass, and lasting and persistent symptoms, resulting in reduced physical activity.
Objective:
To evaluate the effects of a multicomponent training on functional capacity, persistent symptoms, body composition, pulmonary function, and physical activity levels in patients significantly impaired by SARS-CoV-2.
Methods:
The participants were randomly assigned (1:1) to either the intervention group (IG), which received multicomponent training (balance/aerobic/resistance), or the control group (CG). Functional capacity [6 min walk test (6MWT)-primary outcome, sit and reach, sit-to-stand, timed up and go], persistent symptoms (dyspnea, fatigue, post-COVID functional status, frailty), body composition (dual-energy x-ray absorptiometry and bioimpedance), pulmonary function, and physical activity levels (accelerometry) were evaluated at baseline and after 24 weeks. Generalized estimating equations were used, with the significance level set at α = 0.05. Outcomes were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Effect sizes were calculated from the mean difference between groups of changes between pre- and post-intervention.
Results:
Forty participants [age = 52.00 (12.93) years, 19 women] were included. The primary outcome 6MWT showed improvement in both groups in the ITT analysis (IG: 35.5 m, 95% CI: -3.0 to 74.1; CG: 37.4 m, 95% CI: -5.26 to 80.2) and in the IG (87.6 m, 95% CI: 50.6-124.4) in the PP analysis. The IG showed a reduction in mental fatigue (-1.7 points, 95% CI: -0.5 to 3.5) and general fatigue (-6.5 points, 95% CI: -9.4 to -3.5) in our ITT analysis. The IG also revealed improvement in timed up and go test (-1.6 s, 95% CI: -2.6 to -0.6), mental fatigue (-2.0points, 95% CI: -3.6 to 0.7), general fatigue (-6.4points, 95% CI: -11.0 to -1.6), and a protective effect against increased body fat in PP analysis.
Conclusion:
This program was effective in improving fatigue in patients previously significantly affected by COVID-19.
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