AIEgens for in vitro and in vivo pathogen visualization

Area of Science:

• Biomedical Engineering
• Materials Science
• Infectious Disease Diagnostics

Background:

• Infectious diseases pose a significant global health burden.
• Challenges include delayed diagnosis and the rise of multidrug resistance.
• Novel diagnostic tools are crucial for effective disease management.

Purpose of the Study:

• To review recent advancements in the application of aggregation-induced emission luminogens (AIEgens) for infectious disease research.
• To highlight the potential of AIEgens in sensitive pathogen detection and real-time imaging.
• To explore the use of AIEgens in diagnostics and theranostics.

Main Methods:

• Literature review of recent studies on AIEgens in infectious disease applications.
• Analysis of AIEgen properties such as photostability, biocompatibility, and turn-on fluorescence.
• Evaluation of AIEgen-based methods for in vitro and in vivo visualization and diagnostics.

Main Results:

• AIEgens demonstrate high photostability and biocompatibility.
• Their turn-on fluorescence enables sensitive pathogen detection.
• AIEgen-based strategies show promise for real-time imaging and diagnostics.
• Emerging applications in theranostics are being explored.

Conclusions:

• AIEgens represent a powerful platform for advancing infectious disease diagnostics.
• Their unique optical properties facilitate sensitive and real-time pathogen detection.
• Further research into AIEgen-based theranostics could lead to improved patient outcomes.