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Maintenance and Reliever Therapy in Pediatric Asthma: A Concise Review of Recent Evidence-Part I

Rahaf Alharbi1, Adel S Alharbi2

  • 1Pharmaceutical Services Department, and Department of Pediatrics, Pediatric Sleep Disorders Center, Prince Sultan Military Medical City.

Pediatric Annals
|October 8, 2025
PubMed

Insights

Inhaled corticosteroid-long-acting beta 2-agonist (ICS-LABA) therapies are effective for pediatric asthma. Maintenance and Reliever Therapy (MART) offers a potential alternative to improve adherence and outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Pharmacy

Background:

  • Pediatric asthma is a growing global health concern, impacting children's quality of life.
  • Current treatments include inhaled corticosteroids (ICS) and long-acting beta 2-agonists (LABAs).
  • ICS-LABA combinations show efficacy but face challenges in adherence and optimal dosing.

Purpose of the Study:

  • To review current evidence on ICS-LABA therapy for pediatric asthma.
  • To introduce the Maintenance and Reliever Therapy (MART) approach.
  • To evaluate MART as a potential alternative for improved pediatric asthma management.

Main Methods:

  • Literature review of clinical trials and observational studies.
  • Analysis of treatment efficacy, safety, and adherence data.
  • Comparative assessment of ICS-LABA and MART strategies.

Main Results:

  • ICS-LABA combinations effectively reduce asthma exacerbations and improve lung function.
  • Concerns regarding adherence and inflammation masking persist with traditional ICS-LABA use.
  • MART demonstrates potential for enhanced adherence and optimized symptom control.

Conclusions:

  • ICS-LABA therapy remains a cornerstone for pediatric asthma management.
  • MART presents a promising alternative, potentially improving treatment adherence and outcomes.
  • Further research is needed to fully establish MART's long-term benefits in pediatric populations.

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