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Updated: Jan 15, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Water-Promoted Indole Migration of Bis(indol-3-yl)-ynamides Using Zn(OTf)2 as a Lewis Acid Catalyst

Zhanshuai Xiao1, Yin Wei1, Min Shi1

  • 1State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.

The Journal of Organic Chemistry
|October 8, 2025
PubMed
Summary

A novel zinc(II)-catalyzed reaction efficiently synthesizes carbonyl-containing bisindole derivatives using bis(indol-3-yl)-ynamides. This method offers broad scope and functional group tolerance for creating valuable organic compounds.

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