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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Rolling circle replication based nucleic acid nanostructures for programmable drug delivery.

Kyungjik Yang1, Keonwook Nam1, Kyung Hoon Park1

  • 1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. yr36@yonsei.ac.kr.

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|October 8, 2025
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Summary
This summary is machine-generated.

Rolling circle replication (RCR) enables the creation of ultra-long nucleic acid nanostructures for biomedical uses. These advanced nanomaterials offer improved stability and functionality for drug delivery applications.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Biology

Background:

  • Nucleic acid nanostructures offer programmability, biocompatibility, and biodegradability for biomedical applications.
  • Current limitations include inefficient synthesis and degradation in physiological environments.

Purpose of the Study:

  • To review the biological functions and engineering strategies of rolling circle replication (RCR)-based nucleic acid nanostructures.
  • To highlight advances in targeted and stimulus-responsive drug delivery using these nanostructures.

Main Methods:

  • Utilizing rolling circle replication (RCR) for synthesizing ultra-long nucleic acid nanostructures.
  • Reviewing literature on passive, active, and stimulus-responsive delivery systems.

Main Results:

  • RCR produces nucleic acid nanostructures with enhanced productivity, biostability, and functionality.
  • Demonstrated applications in various targeted drug delivery strategies.

Conclusions:

  • RCR-based nucleic acid nanostructures show significant promise for advanced drug delivery.
  • Further research is needed to address current challenges and unlock future potential.