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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Reply to: In Response to Fuller et al., Functional Rating Scale 2.0 (FuRST 2.0): A patient-reported outcome measure

Neha Sinha, Rebecca Lm Fuller1, Glenn T Stebbins2

  • 1CHDI Management/CHDI Foundation, New York, NY, USA.

Journal of Huntington'S Disease
|October 8, 2025
PubMed
Abstract

No abstract available in PubMed .

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...