Palladium-Catalyzed Hydroamination of Vinyl Ethers with Indoles: Efficient Access to N,O-Aminal Indoles
Bowen Wang1,2, Jianxiao Li1, Wanqing Wu1
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, China.
Abstract:
Indole alkaloids represent a privileged class of natural products with significant potential in drug discovery. Herein, an efficient palladium-catalyzed N-alkylation of indoles with vinyl ethers has been developed. This atom-economic hydroamination demonstrates good functional group tolerance and broad substrate scope across diverse indole alkaloids, providing straightforward access to valuable N,O-aminal indole derivatives. This reaction features mild reaction conditions, complete N1-regioselectivity, operational simplicity, and straightforward product transformation.
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