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Updated: Jan 15, 2026
07:28
Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
Published on: July 2, 2018
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Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management
Mengmeng Zhu1, Yiwen Li2, Qian Xu1
1National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine Xiyuan Hospital of China Academy of Chinese Medical Sciences Beijing China.
Medcomm
|October 9, 2025
Summary
Acute myocardial infarction (AMI) research now spans the entire disease course, including multi-organ interactions. This review covers molecular mechanisms, clinical strategies, and future precision-based frameworks for AMI prevention and management.
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Systems Biology
Background:
- Acute myocardial infarction (AMI) is a leading cause of death globally, despite advances in treatment.
- Research has expanded from local injury to the full disease course, including remodeling and organ interactions.
Purpose of the Study:
- To systematically review molecular mechanisms of AMI and ventricular remodeling.
- To explore heart-gut-brain-kidney-liver interactions in AMI.
- To summarize clinical advancements and future directions in AMI management.
Main Methods:
- Systematic literature review of molecular mechanisms.
- Analysis of clinical evolution in diagnostic criteria and management.
- Synthesis of emerging therapeutic strategies and future research.
Main Results:
- Delineation of key molecular pathways in AMI and remodeling.
- Exploration of inter-organ crosstalk in AMI pathogenesis.
- Overview of evolving diagnostic tools (AI integration) and therapies (cellular/genetic).
Conclusions:
- A comprehensive understanding of AMI requires considering systemic effects and inter-organ communication.
- Integrating mechanistic insights with interdisciplinary strategies is crucial for precision-based AMI prevention and management.
- Future research should focus on a holistic, systematic approach to combat AMI.
Keywords:
acute myocardial infarctioninter‐organ crosstalkmyocardial ischemia/reperfusion infarctionpathogenesisventricular remodelingMore Related Videos
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