Related Experiment Video

Updated: Jan 15, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.7K

Challenges and Solutions in Advanced Management of Diabetic Foot Infections: A Review of Recent Studies

Somaye Rashki1, Mohammad Hossein Haddadi2, Zeynab Marzhoseyni3

  • 1Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran.

Journal of Diabetes Research
|October 9, 2025
PubMed

Insights

Diabetic foot infections (DFIs) are serious diabetes complications. Effective management, including early diagnosis and new treatments, is crucial to prevent amputations and reduce healthcare costs.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Microbiology

Background:

  • Diabetic foot infections (DFIs) are a major diabetes complication, causing significant morbidity, mortality, and healthcare expenses.
  • DFIs range from mild to severe, often necessitating hospitalization and potentially leading to limb amputation.
  • Pathogenesis involves neuropathy, vascular issues, and immune dysfunction, worsened by hyperglycemia.

Purpose of the Study:

  • To systematically review the pathogenesis, diagnostics, microbial profiles, and treatments for DFIs.
  • To emphasize the challenges posed by antimicrobial resistance, especially MRSA.
  • To highlight novel therapeutic strategies and the importance of a multidisciplinary approach.

Main Methods:

  • Systematic review of existing literature on diabetic foot infections.
  • Analysis of microbial etiology, pathogenic mechanisms, and diagnostic techniques.
  • Evaluation of current and emerging treatment strategies, focusing on antibiotic resistance.

Main Results:

  • DFIs have diverse microbial origins, including common pathogens like S. aureus and E. coli.
  • Antimicrobial resistance, particularly MRSA, complicates effective treatment.
  • A multidisciplinary approach is essential for optimal DFI management.

Conclusions:

  • Improved management of DFIs is critical due to the rising global diabetes prevalence.
  • Early diagnosis, appropriate antibiotics, advanced wound care, and patient education are key to preventing severe outcomes.
  • Addressing antibiotic resistance and exploring new therapies are vital for reducing amputations and healthcare costs.
Keywords:
diabetesdiabetic foot infectionsdiabetic wounddiagnosispathogenesis of diabetes

More Related Videos

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

14.0K
A Simplified Technique for Producing an Ischemic Wound Model12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.8K

Related Concept Videos

Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
349
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
867
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
376
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
313
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
242