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Bacterial Infections Role in Gynecological Cancers Development: Narrative Review
Robab Azargun1, Maryam Azargoon2, Zahra Asefy1
1Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran.
Cancer Reports (Hoboken, N.J.)
|April 12, 2026
Summary
Bacterial infections like Chlamydia, Mycoplasma, and Bacteroides spp. disrupt the reproductive organ microbiome, potentially causing gynecological cancers. Further research into microbiome balance and infection control is crucial for understanding and treating these cancers.
Area of Science:
- Gynecologic Oncology
- Microbiology
- Cancer Research
Background:
- Gynecological cancers, including ovarian, cervical, and uterine cancers, are prevalent among women.
- The female reproductive tract harbors a delicate microbial balance, which, when disrupted, is linked to various gynecological diseases and cancers.
Purpose of the Study:
- To review recent findings on the role of bacterial infections in the development of gynecological cancers.
- To explore the mechanisms by which bacteria may promote carcinogenesis and cancer progression.
Main Methods:
- Literature review of studies investigating bacterial infections and gynecological cancers.
- Analysis of research linking specific bacterial species to cancer development.
Main Results:
- Bacterial infections can promote cancer development, potentially through inflammation, toxins, and effector proteins.
- Chlamydia, Mycoplasma, and Bacteroides spp. are identified as common bacterial infections associated with gynecological cancers.
Conclusions:
- Evaluating the reproductive organ microbiome in gynecological cancer patients is important.
- Further studies on infection prevention and control could aid in verifying disease pathogenesis and developing therapeutic interventions.
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