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Innovative Regenerative Treatment with Nanofat Injection for Hypertensive Ischemic Leg Ulcer: A Case Report

Mélodie Terrasa1, Marwa Majzoub1, Geraldine Jeudy1

  • 1Service de Dermatologie, CHU de Dijon, boulevard de Maréchal-de-Lattre-de-Tassigny, Dijon, France.

Case Reports in Dermatology
|October 9, 2025
PubMed
Summary

Nanofat injections effectively treated a chronic hypertensive ischemic leg ulcer (HYTILU) in a patient. This regenerative therapy promoted rapid healing, significantly reduced pain, and improved quality of life with no adverse events.

Keywords:
Adipose-derived stromal cellsCase reportHypertensive ischemic leg ulcerNanofatRegenerative medicine

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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