Related Experiment Video
Updated: Jan 15, 2026
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
17.9K
Injectable in-situ curable hydrogel for medullary cavity hemostasis.
Xiangxiao Meng1, Fei Liu2, Chao Shi3
1State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Frontiers in Bioengineering and Biotechnology
|October 9, 2025
Summary
A novel injectable hydrogel, Gel10-Th200, effectively achieves bone hemostasis within the medullary cavity. This advanced material promotes blood clotting and reduces blood loss without external compression, offering a promising solution for challenging bone bleeding scenarios.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Surgical Hemostasis
Background:
- Achieving effective hemostasis within the narrow medullary cavity of bones presents significant clinical challenges.
- Existing methods often require prolonged external pressure and may be insufficient for deep bone injuries.
Purpose of the Study:
- To develop and evaluate an in-situ hemostatic hydrogel for effective hemostasis in the medullary cavity.
- To assess the hemostatic efficacy, biocompatibility, and bone repair potential of the developed hydrogel.
Main Methods:
- Synthesized an injectable hydrogel (Gel10) via Schiff base reaction between dialdehyde-functionalized PEG (DF-PEG) and carboxymethyl chitosan (CMCS).
- Modified Gel10 with thrombin to create Gel10-Th200, enhancing mechanical properties and bioactivity.
- Evaluated hydrogel properties (porosity, water absorption, blood cell aggregation) and tested efficacy in a rabbit medullary cavity hemorrhage model.
Main Results:
- Gel10 exhibited an interpenetrating porous structure, high water absorption (~269%), and promoted blood cell aggregation.
- Gel10-Th200 demonstrated superior mechanical properties and significantly reduced bleeding time and blood loss in the rabbit model compared to gauze.
- Gel10-Th200 achieved hemostasis without external compression, showed excellent cell compatibility, and negligible hemolytic effects.
Conclusions:
- The developed in-situ hemostatic hydrogel (Gel10-Th200) is effective for managing bleeding in the medullary cavity.
- Its injectability, rapid curing, shape adaptability, and enhanced properties make it a promising candidate for challenging bone hemostasis applications.
- Gel10-Th200 supports secondary hemostasis and bone tissue repair, indicating potential for regenerative applications.
