The Sweet Aspects of Orthoflavivirus Treatment Design and Vaccine Development

Viruses in the genus Orthoflavivirus are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad-spectrum treatments and preventive measures for these viral infections in humans. One of the most promising targets for developing treatments or vaccines is glycan molecules, found on both viral and host proteins, which are essential during the infectious cycle. This review examines various antiviral and immunization approaches focused on glycoproteins to fight orthoflavivirus infections.