Exploring the Therapeutic Potential of Fluorouracil in Addressing Skin Aging and Diseases

Fluorouracil (5-FU) belongs to the class of fluorouracil compounds and is commonly used as an anticancer drug for various types of cancer treatment. It inhibits tumor growth by blocking DNA synthesis and cell proliferation, thereby exerting anticancer effects. 5-fluorouracil is commonly used in combination with other chemotherapy drugs to enhance its curative effects and can be administered orally or intravenously. Despite its high bioavailability and tissue distribution rate, 5-fluorouracil may also cause a series of adverse reactions including gastrointestinal symptoms (nausea, vomiting, diarrhea) and bone marrow suppression. The skin is not only the largest organ of the human body but also highly susceptible to external environmental factors and internal influences. Many chronic skin conditions, such as eczema, psoriasis, and skin cancer, can impact the health and youthful appearance of the skin. 5-FU can alleviate inflammation by inhibiting cell proliferation, inducing apoptosis, and suppressing DNA synthesis, thereby treating keloids and other skin issues. Maintaining skin health and adopting effective treatment measures for skin diseases are effective ways to delay skin aging. This study explores the therapeutic potential of fluorouracil in addressing skin aging and diseases, providing new ideas for anti-aging treatments.