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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Two factors primarily cause thromboembolic conditions.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Related Experiment Video

Updated: Jan 15, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

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The Bleeding Disorders Research Collaborative.

Leonard A Valentino1, Maria E Santaella2, Michelle L Witkop2

  • 1Department of Pediatrics, Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL.

Blood Vessels, Thrombosis & Hemostasis
|October 10, 2025
PubMed
Summary
This summary is machine-generated.

The Bleeding Disorders Research Collaborative (BDRC) advances care for inheritable bleeding disorders through research, infrastructure, and community partnerships. It prioritizes health equity and lived experience expertise for improved quality of life.

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Area of Science:

  • Hematology
  • Public Health
  • Health Services Research

Background:

  • Inheritable bleeding disorders affect numerous individuals, necessitating advancements in care standards.
  • Current research infrastructure and workforce capacity may not fully address the needs of this community.
  • Health equity, diversity, and inclusion are critical for improving outcomes in bleeding disorder management.

Purpose of the Study:

  • To establish the Bleeding Disorders Research Collaborative (BDRC) as a model for advancing care in inheritable bleeding disorders.
  • To foster collaborative scientific inquiry and build an efficient research infrastructure.
  • To promote health equity, diversity, inclusion, and community engagement in bleeding disorder research.

Main Methods:

  • Establishing a collaborative research network focused on inheritable bleeding disorders.
  • Developing a coordinated and efficient research infrastructure.
  • Engaging a diverse and capacitated workforce in partnership with affected communities.
  • Integrating principles of health equity, diversity, inclusion, accessibility, and belonging.
  • Incorporating lived experience experts throughout the research process.

Main Results:

  • The BDRC initiative is founded on principles of health equity, diversity, inclusion, and belonging.
  • Lived experience experts are integral to the research development, implementation, and dissemination.
  • A framework for accessible standard of care and improved quality of life is being advanced.
  • Collaborative scientific inquiry is coordinated by an efficient research infrastructure.

Conclusions:

  • The BDRC is poised to significantly improve the standard of care and quality of life for individuals with inheritable bleeding disorders.
  • The collaborative model, emphasizing health equity and community partnership, offers a pathway to health justice.
  • The integration of lived experience experts ensures research is relevant and impactful for the bleeding disorder community.