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Enhancing prostate cancer detection: The role of b-value and apparent diffusion coefficient in DWI
Brian Goveas1, Winniecia Dkhar1, Rajagopal Kadavigere2
1Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Background:
Magnetic Resonance Imaging (MRI) is a highly effective tool for the detection of prostate cancer (PCa). Diffusion-weighted MRI (DW-MRI) is a sensitive technique that depends on the b value and apparent diffusion coefficient (ADC) value for the diagnosis of PCa. The main objective of this study was to determine the optimal b-value and apparent diffusion coefficient (ADC) value in DW-MRI for the diagnosis of prostate cancer.
Methods:
A prospective study including 26 male participants were conducted. MRI examinations were performed with T2 fat saturation sequences, and Diffusion weighted imaging (DWI) sequences with b-values (800, 1000, 1500, and 2000 mm 2/s) were used, and the corresponding ADC maps were calculated. Qualitative and quantitative analyses were conducted.
Results:
According to the present study, a b-value of 0,1500 mm 2/s exhibited the highest Signal-to-Noise Ratio (SNR), and Signal Intensity Ratio (SIR). Area Under the Curve (AUC) for 0,1500 mm 2/s was 0.80, indicating a high diagnostic accuracy for prostate cancer.
Conclusion:
DWI with a b-value of 1500 mm 2/s provides good diagnostic accuracy for differential diagnosis of prostate lesions. DWI is a crucial sequence in multiparametric MRI of the prostate and offers detailed information that enhances the accuracy of prostate cancer diagnosis and management.
