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Updated: Jan 15, 2026
07:04
Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
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Citrus Flavonoids for Cystic Fibrosis Treatment
Mario Pagliaro1, Caterina Di Sano2, Claudia D'Anna2
1Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.
Chembiochem : a European Journal of Chemical Biology
|October 10, 2025
Summary
Citrus flavonoids show potential for treating cystic fibrosis. Formulated flavonoids may offer a multitarget therapy with antimicrobial, anti-inflammatory, and immune-modulating effects for this genetic lung disease.
Area of Science:
- Pharmacology
- Biochemistry
- Genetics
Background:
- Selected citrus flavonoids activate the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
- Cystic fibrosis (mucoviscidosis) is a genetic disease characterized by chronic lung inflammation and bacterial infections.
Purpose of the Study:
- To explore the potential of citrus flavonoids in developing a multitarget treatment for cystic fibrosis.
- To investigate citrus flavonoids for their antimicrobial, anti-inflammatory, CFTR-stimulating, and immunomodulatory properties.
Main Methods:
- Review of studies on citrus flavonoids and CFTR activity since the late 1990s.
- Formulation of citrus flavonoids for potential therapeutic applications.
Main Results:
- Citrus flavonoids demonstrate substantial activity as CFTR activators.
- Potential for a single-treatment formulation combining multiple therapeutic properties.
Conclusions:
- Aptly formulated citrus flavonoids show significant promise for a multitarget cystic fibrosis therapy.
- This approach could address the complex inflammatory and infectious aspects of the disease.
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