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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Updated: Jun 2, 2026

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses
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Published on: September 11, 2023

Borates in Biomedicine: A Retrospective Analysis.

Mario Pagliaro1, Giovanna Li Petri1, Giuseppe Angellotti1

  • 1Istituto per lo Studio dei Materiali Nanostrutturati, CNR, Palermo, Italy.

Chemmedchem
|June 1, 2026
PubMed
Summary

Boron, an essential micronutrient, shows significant therapeutic potential for neurodegenerative diseases, allergies, and cancer. Recent research highlights its benefits in bone health and diabetic wound healing, building on its historical antiseptic use.

Keywords:
aseptinboraxboric acidcalcium fructoboratehormesis

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Last Updated: Jun 2, 2026

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Area of Science:

  • Biochemistry
  • Biomedicine
  • Nutraceuticals

Background:

  • Boron is a vital micronutrient with diverse health benefits.
  • Biochemical and biomedical studies since the 1990s revealed antioxidant, anti-inflammatory, nootropic, anticancer, and antigenotoxic properties of borates.
  • Borates exhibit a hormetic response, showing therapeutic effects at low doses.

Purpose of the Study:

  • To provide a retrospective analysis of borates in biomedicine.
  • To highlight the evolving understanding of boron's therapeutic applications.
  • To offer insights for researchers and policy managers in identifying novel therapeutic agents.

Main Methods:

  • Retrospective analysis of scientific literature on borates.
  • Review of studies from the early 1990s to recent clinical trials (2020-2025).
  • Examination of historical data, including Lister's discovery of boric acid's antiseptic properties in 1875.

Main Results:

  • Borates, including borax and boric acid, possess antioxidant, anti-inflammatory, nootropic, anticancer, and antigenotoxic properties.
  • Recent studies (2020-2025) indicate new uses for borates in biomedicine and nutraceuticals.
  • Applications range from bone and joint health supplements to treatments for diabetic foot ulcers.

Conclusions:

  • Boron compounds offer significant therapeutic potential across various medical fields.
  • The hormetic effects of borates warrant further investigation for drug development.
  • Understanding boron's multifaceted properties provides valuable lessons for therapeutic agent discovery.