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Comparison between Amorphous States of the Trans/Cis Isomers of Clomiphene: Similarities and Differences
Jules Trubert1, Marie-Rose Garda1, Liubov Matkovska1
1Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Groupe de Physique des Matériaux UMR 6634, Rouen F-76000, France.
Abstract:
Amorphous states of clomiphene trans/cis isomers (namely, enclomiphene and zuclomiphene) were isolated by melt cooling procedures. Despite relatively close Tg values (with respect to their respective melting points), both glasses exhibit clear differences in terms of relaxation and molecular mobility as determined by modulated temperature differential scanning calorimetry and broadband dielectric spectroscopy analyzes. Zuclomiphene notably presents more dynamic heterogeneities than its trans counterpart, resulting in drastic differences in secondary and primary relaxations. So far, this study revealed subtle differences between amorphous pairs of trans/cis diastereomers, in contrast to similarities previously observed between pairs of enantiomers.
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