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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Brachial-Ankle Pulse Wave Velocity Is Associated with Kidney Function Decline in Adults Undergoing Cardiovascular

Caroline B Ledet1, Meliksah Arslan2, Kylie Van Dyke2

  • 1Internal Medicine Residency Program, School of Graduate Medical Education, Mayo Clinic, Rochester, Minnesota.

Kidney360
|October 10, 2025
PubMed

Insights

Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is linked to faster kidney function decline and increased chronic kidney disease (CKD) risk in adults screened for cardiovascular disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) affects millions, posing significant health risks.
  • Arterial stiffness is an emerging risk factor for CKD.
  • Brachial-ankle pulse wave velocity (baPWV) offers a non-invasive assessment of arterial stiffness.

Purpose of the Study:

  • To investigate the association between baPWV and kidney function decline.
  • To determine if baPWV predicts CKD development and survival.
  • To assess arterial stiffness as a marker in cardiovascular disease (CVD) screening.

Main Methods:

  • 1,862 patients undergoing CVD screening had baPWV measured.
  • Estimated glomerular filtration rate (eGFRCr) was calculated using CKD-EPI formula.
  • Multivariable regression and survival analyses assessed baPWV's impact on eGFRCr change and CKD risk.

Main Results:

  • A one SD increase in baPWV correlated with a greater yearly decrease in eGFRCr.
  • Higher baPWV levels were associated with increased risk of developing CKD.
  • Elevated baPWV indicated shorter CKD-free survival time.

Conclusions:

  • Elevated baPWV is associated with kidney function decline.
  • Non-invasive baPWV measurement can identify individuals at higher risk for CKD.
  • baPWV is a valuable marker in CVD screening for predicting kidney disease progression.
Abstract

No abstract available in PubMed .

Keywords:
CKDcardiovascular diseasevascular disease

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