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Updated: Jan 15, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Cu-Catalyzed SF4-Alkynylation of Quinolones, Chromones and Cyclohexenones
Muhamad Zulfaqar Bacho1, Yuji Sumii2, Ankit Kumar2
1Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Abstract:
We report the Cu-catalyzed SF4-alkynylation of quinolones, chromones, and cyclohexenones using pyridyl SF4-alkynes under Lewis acid assisted conditions, affording diverse SF4-linked heterocycles in good to high yields. The method leverages the electron-deficient, enone-like character of SF4-alkynes while maintaining broad functional group tolerance. Notably, the SF4 unit remains stable under oxidative and acidic conditions, enabling efficient ring-reconstruction from six- to five-membered heterocycles. This strategy provides access to regulation-friendly fluorinated scaffolds with significant potential in medicinal chemistry.
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