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Related Experiment Video

Updated: Jan 15, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Phenotyping asthma and/or chronic obstructive pulmonary disease using 129Xe MRI and comprehensive physiologic

Helen Marshall^1,2, Laurie J Smith¹, Alberto M Biancardi^1,2

¹POLARIS, Section of Medical Imaging and Technologies, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.

American Journal of Respiratory and Critical Care Medicine

|October 10, 2025

Summary

Hyperpolarized xenon-129 MRI and pulmonary function tests can distinguish between asthma and COPD phenotypes. This imaging technique aids in diagnosing airway diseases and guiding treatment for patients with asthma and/or COPD.

Keywords:

COPD asthma pulmonary function tests xenon-129 MRI

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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

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Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Published on: January 5, 2024

Area of Science:

Pulmonary Medicine
Medical Imaging
Respiratory Physiology

Background:

Asthma and COPD share diagnostic criteria but have distinct treatments and outcomes.
Patients with co-existing asthma and COPD (asthma+COPD) experience poorer clinical results.
Hyperpolarized xenon-129 MRI (129Xe MRI) and pulmonary function tests (PFTs) assess lung function and structure.

Purpose of the Study:

To evaluate if 129Xe MRI combined with PFTs can aid in phenotyping patients with asthma and/or COPD.
To identify distinct imaging and functional signatures for different respiratory disease groups.

Main Methods:

Recruited 165 adult patients diagnosed with asthma and/or COPD from primary care.
Assessed patients using 129Xe MRI, proton MRI, spirometry, oscillometry, nitrogen washout, and TLco post-bronchodilator.
Analyzed differences in 129Xe MRI and PFT metrics across diagnostic groups.

Main Results:

Significant differences in 129Xe MRI and PFT metrics were observed between asthma, COPD, and asthma+COPD groups.
COPD patients showed reduced, heterogeneous ventilation, larger acinar dimensions, and lower gas transfer on 129Xe MRI compared to asthma patients.
129Xe MRI identified abnormalities even in patients with normal spirometry or TLco, highlighting its sensitivity to early or subtle lung disease.

Conclusions:

129Xe MRI and PFTs provide distinct airway disease signatures, aiding in the diagnosis of asthma and/or COPD.
129Xe MRI is highly sensitive to minimal lung disease, identifying functional and structural phenotypes.
These findings may help guide personalized treatment decisions for respiratory conditions.