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Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Six undescribed geranylated flavonoid derivatives isolated from Macaranga denticulata with potent Zika virus
Jia-Bi Huang1, Yong-Xiang Huang2, Meng-Ru Wang1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, PR China.
Abstract:
Six undescribed geranylated flavonoid derivatives (1-6), together with two known compounds (7-8), were isolated from Macaranga denticulata Müll. Arg. (family Euphorbiaceae). Their structures were characterized by detailed spectroscopic analysis and by comparison with literature data. Moreover, compound 4 exhibited potent Zika virus inhibitory activity, with EC50 value of 8.72 μM. Compound 4 showed low cytotoxicity to Vero cells, with CC50 value exceeding 100 μM. Hence, compound 4 may be developed as potential anti-ZIKV agents.

