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Related Experiment Video

Updated: Jan 15, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Characterizing chronic obstructive pulmonary disease using quantitative MRI biomarkers.

Daniel Genkin1, Kalysta Makimoto1, Miranda Kirby1

  • 1Toronto Metropolitan University, . Toronto, Canada.

The British Journal of Radiology
|October 10, 2025
PubMed
Summary

Magnetic resonance imaging (MRI) offers a radiation-free method to assess chronic obstructive pulmonary disease (COPD) structural and functional changes. Quantitative MRI biomarkers show promise for understanding COPD progression and outcomes.

Keywords:
BiomarkersCOPDImagingLungsMRIQuantitative

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Biomedical Imaging

Background:

  • Chronic obstructive pulmonary disease (COPD) involves structural and functional lung abnormalities.
  • Computed tomography (CT) is standard for COPD structural assessment but uses radiation and lacks functional data.
  • Magnetic resonance imaging (MRI) advancements enable non-ionizing radiation assessment of lung structure and function.

Purpose of the Study:

  • To review MRI techniques for lung imaging in COPD.
  • To discuss quantitative MRI (qMR) biomarkers for COPD assessment.
  • To identify research gaps for qMR implementation in COPD.

Main Methods:

  • Review of commonly used MRI techniques for lung imaging.
  • Discussion of established qMR imaging biomarkers.
  • Analysis of qMR biomarker applications in COPD studies.

Main Results:

  • qMR imaging biomarkers quantify parenchymal, airway, ventilation, and perfusion abnormalities in COPD.
  • Investigated qMR biomarkers show associations with COPD outcomes in cross-sectional and longitudinal studies.
  • MRI provides functional insights without ionizing radiation, unlike CT.

Conclusions:

  • MRI and its qMR biomarkers are valuable tools for COPD research, offering radiation-free structural and functional assessment.
  • Further research is needed to address literature gaps for widespread qMR implementation in COPD.
  • qMR imaging holds potential for advancing COPD understanding and patient management.