Breast Findings in Females With Beckwith-Wiedemann Syndrome

Beckwith-Wiedemann syndrome (BWS) is an overgrowth condition caused by epigenetic defects on chromosome 11p15. Children with BWS have a predisposition to embryonal tumors such as Wilms tumor and hepatoblastoma. However, few reports of breast tumors in females with BWS have been published and the risk of malignancy and need for screening remains unknown. In this report, we describe six adolescent or adult females with BWS who developed benign or malignant breast tumors. Additionally, we conducted a review of the literature to compare our findings with previously reported cases.