Related Experiment Video

Updated: Jan 15, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

340

Toward Combinatorial Strategies to Improve Proximal Tubule Recovery Following Acute Kidney Injury

David A Bastos1, Lisa O Oti2, Carla L Ellis3

  • 1Department of Medicine, Division of Nephrology & Hypertension, Feinberg Cardiovascular & Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Seminars in Nephrology
|October 11, 2025
PubMed

Insights

Kidney disease affects millions globally. Understanding diverse cellular responses to acute kidney injury, particularly in proximal tubule cells, is crucial for developing targeted therapies to prevent chronic kidney disease progression.

Area of Science:

  • Nephrology
  • Cellular Biology
  • Pathophysiology

Background:

  • Kidney disease is a major global health issue affecting 850 million people.
  • Many kidney diseases progress asymptomatically, delaying diagnosis and treatment.
  • Renal injury can lead to severe health consequences, necessitating advanced medical interventions.

Purpose of the Study:

  • To review cellular states arising after acute ischemic kidney injury.
  • To identify cellular states that may contribute to the progression to chronic kidney disease.
  • To focus on the heterogeneous responses of proximal tubule cells to ischemic injury.

Main Methods:

  • Review of preclinical animal studies on ischemic kidney injury.
  • Analysis of cellular states in the proximal tubule segment.
  • Identification of repaired and failed-repair cellular states.

Main Results:

  • Acute ischemic kidney injury induces diverse cellular states in the proximal tubule.
  • Heterogeneous cellular responses, including failed repair, are observed.
  • These cellular states are hypothesized to promote the transition to chronic kidney disease.

Conclusions:

  • Understanding heterogeneous cellular states post-injury is key for precision therapeutics.
  • Targeting specific cellular states or pathological processes may prevent chronic kidney disease.
  • Further research into proximal tubule cell responses can inform therapeutic strategies.
Keywords:
AKI-CKDTNIKVCAM-1failed-repairischemic acute kidney injury

More Related Videos

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

483
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.9K

Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
296
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
260
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
890
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
572
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
384
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
817