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Mapping a reproducible water fraction and T1 using MP2RAGE and variable flip angle quantitative MRI protocols.
Eden Mama1, Rona Shaharabani1, José P Marques2
1The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Magnetic Resonance in Medicine
|October 13, 2025
Summary
Water fraction (WF) estimation using the MP2RAGE protocol shows high agreement with the traditional VFA method. This validates MP2RAGE for reliable WF mapping, expanding its use in quantitative MRI studies.
Area of Science:
- Quantitative MRI techniques
- Medical imaging analysis
- Biophysical parameter mapping
Background:
- Water fraction (WF) estimation is crucial for quantitative MRI.
- The variable flip angle (VFA) approach is the standard for WF mapping.
- Exploring alternative protocols like MP2RAGE can enhance WF estimation.
Purpose of the Study:
- To extend WF estimation to the MP2RAGE protocol.
- To compare WF values derived from MP2RAGE and VFA methods.
- To assess the consistency and reliability of WF mapping across acquisition strategies.
Main Methods:
- Calculated WF and T1 maps using both VFA and MP2RAGE protocols.
- Utilized in vivo and phantom datasets for cross-validation.
- Evaluated repeatability and reproducibility within and between protocols.
Main Results:
- Demonstrated high agreement between WF maps from VFA and MP2RAGE.
- Successfully validated WF map extraction from the MP2RAGE protocol.
- Confirmed the consistency of WF estimation across both acquisition methods.
Conclusions:
- Supports the use of WF mapping with both VFA and MP2RAGE protocols.
- Reliable WF estimates can be obtained from either method.
- Expands the applicability of WF mapping in diverse imaging studies.
