U.S. Veterans Using Remote Electrical Neuromodulation for Migraine: A Prospective Real-World Evidence Study of...

Area of Science:

• Neurology
• Medical Devices
• Pain Management

Background:

• Migraine and headache disorders are prevalent in U.S. veterans, often co-occurring with other conditions.
• Effective, well-tolerated, drug-free treatments are needed for this population.
• Remote electrical neuromodulation (REN) is a non-pharmacological wearable device for acute and preventive migraine treatment.

Purpose of the Study:

• To evaluate treatment patterns, acute medication use, effectiveness, and safety of the REN wearable in U.S. veterans.
• To assess the real-world evidence (RWE) of REN for migraine management in veterans.
• To determine the potential of REN as a drug-free therapeutic option for veterans with migraine.

Main Methods:

• A prospective RWE cohort study of veterans prescribed REN.
• Data collected via the REN mobile application (Nerivio).
• Outcomes included rescue medication use, pain relief, functional disability, associated symptoms, and adverse events.

Main Results:

• Over 28,000 REN treatments were analyzed in 466 veterans.
• 76.7% of treatments did not require prescribed rescue medications.
• Significant pain relief (66.7%), functional disability relief (69.3%), and associated symptom relief (56.5%) were reported.
• Higher effectiveness was observed with early treatment initiation and in females.

Conclusions:

• REN is an effective and safe acute migraine treatment for veterans.
• Most veterans did not need prescribed rescue medications when using REN.
• REN offers a clinically relevant, drug-free option for veterans, supporting its integration into care.