Related Experiment Video
Updated: Jan 15, 2026
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
A Rare Case of Hyperhemolytic Syndrome During Pregnancy
Background:
Hyperhemolytic syndrome (HS) is a rare and fatal complication of blood transfusion. This is the first reported case of HS in a Chinese pregnant woman.
Methods:
Here, we report a case of HS in a 22-year-old pregnant Chinese woman with β-thalassemia.
Results:
All red blood cell alloantibody screens, including RBC eluate, were negative; however, the patient had se-vere hemolytic transfusion reactions. She was diagnosed with HS, and her newborn was delivered at 36 weeks and was discharged with a good prognosis.
Conclusions:
This is the first reported case of HS in a Chinese pregnant woman, highlighting the need for further research in the Chinese population. Our successful perinatal management can provide clinical guidance for pregnant women with limited treatment options.
Related Concept Videos
01:19Rh Blood Group
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:27Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
01:10Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...