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Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

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Updated: Jun 17, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Repurposing Neurological Drugs Against Dengue Virus Infection.

Ming-Kai Jhan¹, Ting-Jing Shen², Thi Thuy Nguyen³

¹Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.

Journal of Tropical Medicine

|October 13, 2025

Summary

This summary is machine-generated.

Dengue virus (DENV) can cause neurological complications. This review explores how central nervous system (CNS) drugs may treat DENV infection, offering a promising therapeutic strategy.

Keywords:

CNS dengue fever dengue virus drug repurposing nervous system–acting compounds nervous system–targeted compounds neurological complications of dengue potential treatment options

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Last Updated: Jun 17, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

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Published on: October 11, 2013

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Area of Science:

Neuroscience
Virology
Pharmacology

Background:

Dengue virus (DENV) is a significant global health concern, prevalent in tropical and subtropical areas.
DENV infection presents a range of symptoms, with severe cases leading to dengue hemorrhagic fever and shock syndrome.
Neurological complications of DENV infection are increasingly recognized, yet the underlying mechanisms require further elucidation.

Purpose of the Study:

To review the neurotropic characteristics of DENV.
To summarize existing evidence on the antiviral properties of central nervous system (CNS)-acting drugs against DENV.
To explore potential mechanisms through which these drugs might combat DENV infection.

Main Methods:

Literature review of studies on DENV neurotropism.
Analysis of research on CNS-targeting drugs with antiviral effects on DENV.
Exploration of proposed mechanisms of action for neuropharmaceuticals against DENV.

Main Results:

DENV exhibits neurotropic features, affecting the central nervous system.
Several CNS-acting compounds demonstrate potential antiviral activity against DENV.
Repurposing existing CNS drugs offers a viable therapeutic avenue for DENV infection.

Conclusions:

Understanding DENV's neurotropic effects is crucial for developing targeted therapies.
CNS-targeting drugs show promise for managing DENV-induced neurological complications.
Neuropharmaceutical agents represent a potential strategy for novel antiviral treatments against DENV.