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Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs
Published on: June 6, 2025
Eye-opener: Lateral canthotomy in pigs: A randomised study
Friedrich Lersch1, Pascal Jerney1, Kati Haenssgen1
1From the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FL, PJ), FMI, Spitäler Frutigen Meiringen Interlaken AG, Unterseen, Switzerland (PJ), Institute of Anesthesiology and Intensive Care, Salemspital, Hirslanden Medical Group, Bern, Switzerland (JB-E), Institute for Medical Education, University of Bern, Bern, Switzerland (JB-E), CINTESIS@RISE, Centre for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal (JB-E), Institute of Anatomy, University of Bern, Bern, Switzerland (KH), and Division of Veterinary Anatomy, Department of Clinical Research and Veterinary Public Health, Vetsuisse-Faculty, University of Bern, Switzerland (KH).
Background:
Regional Anaesthesia of the eye, including techniques like retrobulbar, peribulbar, and sub-Tenon's block, is essential for a wide range of ophthalmologic surgeries. These techniques carry risks of severe complications as retrobulbar haemorrhage and infraorbital compartment syndrome, potentially entailing vision loss. Lateral canthotomy with inferior cantholysis (LCIC) is a crucial emergency procedure to manage such complications, and its proficiency among clinicians is vital.
Objective:
This study aims to validate a pig-head teaching model by investigating intra-ocular pressure (IOP) variations during simulated intra-orbital haemorrhage and following LCIC procedure.
Design:
Randomised comparative study.
Setting:
Single centre, tertiary university hospital, Berne, Switzerland, January and February 2023.
Subjects:
Thirteen fresh porcine heads from the local abattoir were used to create a model of retrobulbar haemorrhage.
Interventions:
After visual inspection, we injected 25 ml of hydroxyethyl starch to simulate haemorrhage. IOP measurements were taken at baseline (T0), after injection (T1), immediately after LCIC (T2), and 10 min post-LCIC (T3). The LCIC procedure was performed on randomly selected eyes. Spontaneous regression of intra-ocular pressure was studied without LCIC being performed in control eyes.
Main Outcome Measures:
The primary outcome was the difference in IOP trends between the LCIC and control groups. Secondary outcomes included the rate and extent of IOP reduction post-LCIC. Descriptive statistics and repeated measures ANOVA were used to analyse IOP measurements, with posthoc analysis applied where significant differences were found.
Results:
Baseline IOP showed no significant differences between groups. Postinjection IOP increased significantly in all eyes. LCIC resulted in a median IOP decrease of -45.8 mmHg, compared to -20.9 mmHg in the control group (P = 0.002). The target IOP decrease rate of ≥3 mmHg per minute was achieved only in the LCIC group.
Discussion:
LCIC significantly reduced IOP immediately and 10 min postprocedure compared to controls in simulated retrobulbar haemorrhage. The study supports the clinical utility of the LCIC procedure in managing acute orbital compartment syndrome and validates the pig head model as training device of moderate to high fidelity.
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