Related Experiment Video

Updated: Jan 15, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.1K

The role of long intergenic non-protein coding RNA 312 in cancer: A bioinformatics and literature based study

Arash Safarzadeh1, Setareh Ataei1, Soudeh Ghafouri-Fard1

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biochemistry and Biophysics Reports
|October 13, 2025
PubMed

Insights

The long non-coding RNA LINC00312 acts as a tumor suppressor, with its decreased expression linked to various cancers and poor patient survival. This study explores its role in cancer, highlighting its potential as a diagnostic and prognostic biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • LINC00312 is an intronless transcript primarily functioning as a tumor suppressor.
  • Its expression is notably downregulated in numerous cancers, especially lung cancer.
  • LINC00312 acts as a negative regulator of estrogen receptor signaling.

Purpose of the Study:

  • To investigate the significance of the long non-coding RNA LINC00312 across diverse cancer types.
  • To elucidate the regulatory network and molecular interactions of LINC00312.
  • To assess its potential as a diagnostic and prognostic biomarker in oncology.

Main Methods:

  • Bioinformatics analysis of LINC00312 expression and its associated pathways.
  • Literature review to consolidate existing knowledge on LINC00312 function.
  • Correlation analysis between LINC00312 expression levels and patient survival data.

Main Results:

  • Downregulation of LINC00312 is observed in multiple cancers, including lung cancer.
  • Low LINC00312 expression correlates with poorer survival outcomes in sarcoma and stomach adenocarcinoma.
  • LINC00312's regulatory network and interactions with biomolecules and compounds were identified.

Conclusions:

  • LINC00312 functions as a tumor suppressor and its reduced expression is a hallmark of several cancers.
  • LINC00312 shows promise as a prognostic biomarker, indicated by its association with patient survival.
  • LINC00312 represents a potential candidate for future diagnostic and prognostic applications in cancer management.
Keywords:
BioinformaticsCancerLINC00312

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.8K
DNA Vector-based RNA Interference to Study Gene Function in Cancer13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

21.0K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.3K