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Updated: Jan 15, 2026

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
AIE Ir(III) complex conjugated with biotin as a photosensitizer for enhanced photodynamic anticancer therapy
Zihan Wu1, Runlin Wang1, Chunguang Shi1
1Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China. zhudx047@nenu.edu.cn.
Abstract:
The first aggregation induced emission (AIE) Ir(III) complex bearing a biotin-functionalized ligand, Ir-Bio, is reported. Ir-Bio generates type I and type II reactive oxygen species and has an excellent photodynamic therapy effect in cancer cells.
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