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Neuromodulation for Tourette syndrome: current techniques and future perspectives.
Sarah Haslam1, Kara A Johnson2, Daria Anderson1
1School of Biomedical Engineering, University of Sydney, Camperdown, NSW, Australia.
Journal of Neural Engineering
|October 13, 2025
Summary
Neuromodulation, particularly deep brain stimulation (DBS), shows promise for Tourette syndrome (TS) treatment, reducing tics by 50%. Future strategies aim to improve less-invasive options and understand TS pathophysiology for better therapies.
Area of Science:
- Neurology
- Neuroscience
- Biomedical Engineering
Background:
- Tourette syndrome (TS) is a chronic tic disorder with significant quality of life impacts.
- Current treatments like behavioral therapy and medications offer limited benefits.
- Neuromodulation presents a viable therapeutic strategy for TS.
Purpose of the Study:
- To review current neuromodulation therapies for TS.
- To propose future treatment strategies.
- To enhance understanding of TS pathophysiology and treatment response biomarkers.
Main Methods:
- Review of existing literature on neuromodulation techniques for TS.
- Analysis of deep brain stimulation (DBS) efficacy and limitations.
- Discussion of strategies for advancing TS neuromodulation research.
Main Results:
- Deep brain stimulation (DBS) demonstrates the highest efficacy, averaging a 50% reduction in tics.
- The invasive nature of DBS limits its widespread adoption.
- Less-invasive neuromodulation techniques show limited efficacy.
Conclusions:
- Neuromodulation, especially DBS, offers significant tic reduction in TS.
- Further research is needed to develop less-invasive and more effective neuromodulation strategies.
- Multicenter data sharing and advanced analytical techniques can accelerate progress in TS treatment.
