Four new polyynes and sesquiterpenoids from Atractylodes chinensis
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Published on: December 8, 2023
Yunjing Xing1, Mingzhen Liu1, Jialin Zhang1
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Abstract:
A systematic phytochemical study was carried out on the ethanol extract of the dried rhizomes of Atractylodes chinensis. Eleven compounds were successfully isolated, including two new polyyne compounds atractylodes A (1) and B (2), two new sesquiterpenoid ones atractylodes C (3) and D (4), and seven known ones (5-11). All the compounds were determined by high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculations. In vitro, anti-tumor activity experiments showed that compounds 3 and 4 exhibited remarkable cytotoxic activities against human gastric cancer cells (SGC-7901) with IC₅₀ values of 8.32 ± 1.38 μM and 19.78 ± 1.69 μM, respectively.
