Two new meroterpenoids with 6/10/5/3 tetracyclic skeleton from fungus Ampulloclitocybe clavipes
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Updated: Jun 29, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Zhaocui Sun1, Qiao Wu1, Mingzhen Liu1
1National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Abstract:
Two new meroterpenoids, clavilactones R (1) and S (2) with 6/10/5/3 tetracyclic skeleton, and one known meroterpenoid clavilactone E were isolated from the fungus Ampulloclitocybe clavipes. Their chemical structures, including absolute configurations, were unambiguously determined through HR-ESI-MS, 1D/2D-NMR spectral data and ECD calculations. All three compounds were evaluated for their in vitro cytotoxic activities. Among them, clavilactone S (2) exhibited moderate cytotoxic activity against HGC-27 and A549 tumour cell lines, with IC50 values of 19.2 and 24.8 µM, respectively. Clavilactone R (1) showed weak cytotoxicity, while clavilactone E (3) displayed no obvious cytotoxic effect (IC50 > 50 μM) against both cell lines.
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