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Ketamine-induced sclerosing cholangitis: a case series
A Vanrusselt1, J Nijs1, L Van den Bergh1
1Sint-Trudo Ziekenhuis, Diestersteenweg 100, 3800 Sint-Truiden, Belgium.
Acta Gastro-Enterologica Belgica
|October 13, 2025
Summary
Ketamine-induced sclerosing cholangitis is an emerging liver condition linked to chronic ketamine use. This case series highlights two female patients, expanding understanding of this under-recognized hepatobiliary complication.
Area of Science:
- Hepatology
- Toxicology
- Gastroenterology
Background:
- Ketamine-induced sclerosing cholangitis (KSC) is an emerging condition associated with chronic recreational ketamine use.
- While ketamine's bladder effects are known, its hepatobiliary complications, like KSC, are less understood.
- The exact mechanism of KSC is unclear but may involve ketamine's effect on N-methyl-D-aspartate receptors in bile duct smooth muscle, leading to inflammation and fibrosis.

