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Evaluating patients with Kawasaki disease: can the systemic immune inflammation index predict coronary involvement?

Merve Korkut Oğuz1, Dolunay Gürses1, Münevver Yılmaz1

  • 1Pediatric Cardiology, https://ror.org/01etz1309Pamukkale University School of Medicine, Denizli, Türkiye.

Cardiology in the Young
|October 14, 2025
PubMed

Insights

The Systemic Immune-Inflammation Index may predict coronary artery issues in children with Kawasaki disease. This inflammatory biomarker, calculated from routine blood tests, shows higher levels in patients with coronary artery lesions.

Area of Science:

  • Pediatrics
  • Immunology
  • Cardiology

Background:

  • Kawasaki disease is a vasculitis with potential coronary artery complications.
  • Identifying prognostic biomarkers for Kawasaki disease is crucial for managing coronary involvement.

Purpose of the Study:

  • To evaluate the prognostic role of the Systemic Immune-Inflammation Index (SII) in Kawasaki disease.
  • To determine if SII can predict coronary artery involvement in pediatric patients.

Main Methods:

  • A case-control study included 62 children with Kawasaki disease and 49 healthy controls.
  • Systemic Immune-Inflammation Index (SII) was calculated using neutrophil, platelet, and lymphocyte counts.
  • Statistical analysis compared SII levels between patients and controls, and within Kawasaki disease subgroups.

Main Results:

  • Systemic Immune-Inflammation Index (SII) was significantly higher in Kawasaki disease patients compared to controls (2373 ± 2040 vs. 300 ± 218, p < 0.001).
  • Kawasaki disease patients with coronary artery lesions exhibited significantly higher SII levels than those without (p < 0.05).

Conclusions:

  • Systemic Immune-Inflammation Index (SII) is a readily available inflammatory biomarker derived from routine blood parameters.
  • SII may serve as an independent predictor of coronary artery involvement in Kawasaki disease, aiding in risk stratification.

Keywords:
KawasakiSystemic Immune-Inflammation Indexcoronary involvement

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