Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum

Six undescribed meroterpenoids, designated as hyperwightianols I-N (1-6), were isolated from the dried whole herb of Hypericum wightianum. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds 1-3 featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while 4-6 were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.