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Magoxylignols A-F, six new oxyneolignans from Magnolia officinalis var. biloba
Wei-Ming Huang1,2, Ping Ying1,2, Qiang Zheng1
1Modern Industrial College of Traditional Chinese Medicine and Health, Lishui University, Lishui 323000, China.
Abstract:
Six undescribed oxyneolignans, magoxylignols A-F (1-6), were isolated from Magnolia officinalis var. biloba. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1-6, the first examples of dimeric oxyneolignans reported in M. officinalis var. biloba, were formed by linking honokiol- or magnolol-derived units through an additional C3 side chain. Evaluation of the isolates for anti-inflammatory effects revealed that 1-5 significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting IC50 values ranging from 4.85 to 6.63 μM.
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