Integrative Oncology Approaches Beneficial to Patients in Radiation Therapy

Radiation therapy (RT) remains a cornerstone of multidisciplinary cancer treatment but is frequently associated with acute and chronic toxicities that negatively impact patient quality of life and treatment adherence. This review examines evidence-based integrative oncology interventions-encompassing nutrition, phytochemicals, mind-body therapies, acupuncture, and homeopathy-and their role in mitigating RT-related side effects and supporting patient-centered care.

Emerging clinical trials and meta-analyses have demonstrated that specific integrative strategies can significantly reduce common toxicities associated with RT. Probiotic supplementation lowers the incidence of radiation-induced diarrhea, while high-fiber diets and omega-3 fatty acids may enhance gastrointestinal tolerance and limit therapy resistance. Acupuncture has shown efficacy in managing chronic xerostomia, and calendula-based topical treatments have been effective for radiation dermatitis. Mind-body interventions-including cognitive behavioral therapy, hypnosis, yoga, and mindfulness-based stress reduction-have consistently improved fatigue, anxiety, and overall well-being. Importantly, many of these interventions are low risk, feasible to implement, and increasingly incorporated into supportive oncology care. Integrative oncology offers a valuable complement to modern RT by reducing treatment-related toxicity and enhancing quality of life. As precision medicine advances the ability to tailor RT based on clinical and genomic risk, the integration of evidence-based supportive therapies aligns treatment with patient goals and promotes resilience. Ongoing research will further clarify best practices for incorporating these interventions into routine care, ensuring radiation oncology evolves to meet the dual goals of disease control and holistic patient well-being.