Two new alkaloids were isolated from Portulaca oleracea L. and their bioactivities

Portulaca oleracea L. was commonly used to treat colitis in ancient China, but the therapeutic substances were unclear. As alkaloids are the major chemical compositions of the plant, they were therefore investigated in this research. The compounds oleraglycerolpyridin (1) and olerapyrrolidinone (2) were separated from the Portulaca oleracea L. The structures were verified by NMR and HR-MS, subsequently, their bioactivities were respectively evaluated by determination of IL-1β, TNF-α by ELISA method, and acetylcholinesterase activities by modified Ellman's method.